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doi:10.1001/jama.2023.2438 Supply update

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The peptide acts as an agonist at the ghrelin/GHS receptor, stimulates Gq and Go signaling, increases intracellular calcium in somatotrophs, triggers exocytosis of GH-containing vesicles, and may also stimulate GHRH release and reduce somatostatin at the hypothalamic level

Obesity-induced insulin resistance and lipid dysregulation drive sarcopenia by suppressing IRS-1/Akt/mTOR-mediated protein synthesis 4,7